Mitochondrial Replacement Therapy: Halachic Considerations for Enrolling in an Experimental Clinical Trial
نویسندگان
چکیده
The transition of new biotechnologies into clinical trials is a critical step in approving a new drug or therapy in health care. Ethically recruiting appropriate volunteers for these clinical trials can be a challenging task for both the pharmaceutical companies and the US Food and Drug Administration. In this paper we analyze the Jewish halachic perspectives of volunteering for clinical trials by focusing on an innovative technology in reproductive medicine, mitochondrial replacement therapy. The halachic perspective encourages individuals to volunteer for such clinical trials under the ethical principles of beneficence and social responsibility, when animal studies have shown that health risks are minimal.
منابع مشابه
Group Emotion Regulation Therapy for Illness Anxiety Disorder: A Randomized Controlled Trial
Background & Objective: People with Illness Anxiety Disorder experience excessive worry and in this regard, they have a lot in common with Generalized Anxiety Disorder. Emotion Regulation Therapy (ERT) is a multifaceted and integrated treatment that is widely used for Generalized Anxiety Disorder and its effectiveness in anxious factors has been established in many studies. The aim of the pres...
متن کاملCRISPR/Cas9 and mitochondrial gene replacement therapy: promising techniques and ethical considerations.
Thousands of mothers are at risk of transmitting mitochondrial diseases to their offspring each year, with the most severe form of these diseases being fatal [1]. With no cure, transmission prevention is the only current hope for decreasing the disease incidence. Current methods of prevention rely on low mutant maternal mitochondrial DNA levels, while those with levels close to or above thresho...
متن کاملHypothesis: multiple factors are associated with the lack of any beneficial effects of oestrogen-replacement therapy in the late postmenopausal stage.
1. Epidemiological and clinical studies suggest that women may obtain cognitive benefits from oestrogen-replacement therapy (ERT) during menopause transition rather than in the post-menopausal stages. However, the underlying mechanisms remain to be determined. 2. We propose that long-term oestrogen deficiency may result in abnormal distribution and localization of brain oestrogen receptors, bra...
متن کاملEffectiveness of Transpersonal Therapy (Spiritual Therapy, Yoga-Meditation) in Reducing Fear of Cancer Recurrence in Breast Cancer Survivors: A Randomized Controlled Trial
Introduction: Psycho-spiritual therapy (mind-body spirituality) is a multidimensional, transpersonal, and integrative intervention for breast cancer survivors. This study aimed to determine the effectiveness of counseling based on transpersonal psychotherapy (spirituality therapy, mind and body) in reducing the fear of recurrence in breast cancer survivors. Methods: This was a randomized contro...
متن کاملThe Effectiveness of Dialectical Behavior Therapy on Quality of Life Among Women with Overweight and Binge Eating Disorder: A Clinical Trial
Background and Objectives: Researches have shown that overweight is associated with an increased risk of eating disorders and consequently, leads to a decreased quality of life.. Therefore, the treatment that targets both overweight and eating disorders is vital. So, This study was designed to determine the effect of dialectical behavior therapy on quality of life in women with overweight an...
متن کامل